|
|
| |
New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase. It is rather interesting to note that people like reading about cherry juice and gout if they are presented in an easy and clear way. The presentation of an article too is important for one to entice people to read it!
 |
60-Day Risk FREE Trial
People Said About Goutezol Gout Relief
| "My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY |
 |
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension. It is always better to have compositions with as little corrections in it as possible. This is why we have written this composition on cherry juice and gout with no corrections for the reader to be more interested in reading it.
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers. Do not judge a book by its cover; so don't just scan through this matter on cherry juice and gout. read it thoroughly to judge its value and importance.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least. The presentation of an article on cherry juice and gout plays an important role in getting the reader interested in reading it. This is the reason for this presentation, which has gotten you interested in reading it!
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways. We were actually wondering how to get about to writing about cherry juice and gout. However once we started writing, the words just seemed to flow continuously!
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels. Some of the matter found here that is pertaining to cherry juice and gout seems to be quite obvious. You may be surprised how come you never knew about it before!
|
|
100% Natural and Safe Remedy
People Said About Goutezol Gout Remedy
| "I've been suffering from gout for over 3 years. I tried many different remedies. After taking your product for 20 days I felt the difference. I'm ordering 3 more bottles to make sure I'm not going to have attack any time soon." Bill, FL |
|
HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes. It is with much interest that we got about to write on cherry juice and gout. So we do hope that you too read this article with the same, if not more interest!
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
|
|
|
|
| |
| |
|
|
|
|
|
|
| |
| |
Learn More about Natural Gout Remedy
b>Osteoarthritis: Cause and Symptoms
In our last article, we briefly discussed Osteoarthritis and
Rheumatoid Arthritis. This article will take a close look at the
cause, symptoms, and current treatment used for Osteoarthritis.
So let's take a second look at what Osteoarthritis is.
Osteoarthritis is known by many as "wear and tear" Arthritis. It
is one of the most common forms of... 
Gout is another from of arthritis, which is known to case sudden attacks. The gout causes are known, but unfortunately this condition can not be cured. Treatments only help in reducing the severity of the gout symptoms and to prevent, as much as possible, further gout flares.
This particular arthritis type manifests itself through sudden, painful attacks. Gout attacks develop very...
"Ouch" It's midnight and you are awakened by a horrific pain shooting through your big toe. The throbbing toe is red and swollen and feels as if it's on fire. If you or a loved one can relate to this experience, chances are likely that you suffer from gout. Numerous questions plagued your mind like "Can I survive another night with this pain?"....so we narrowed down your most important...
There are many effective alternative remedies for gout and many of them are not even suggested by doctors. If you are suffer the most painful form of arthritis, gout, it is time you begin to prioritize your health and try simple natural health remedies that work by reducing uric acid levels.
It is the middle of the night and you awake to...
One of the most common forms of arthritis is gout. Gout is characterized by joint inflammation accompanied by terrible pain and sometimes red, shiny skin covering the joint. An attack of gout appears suddenly, often overnight and most often affects the feet and ankles, with the most common area being the ball of the large toe. Gout can be cured by using natural products such as cherries,...
low purine vegetables | kidney stones in cats | cherry juice and gout | special diet for gout | oatmeal and uric acid | kidney stone medicine |
|
|
|
| |
| |
|
|
| |
|
|
|
|
